I came across a great video by David Davis at VMwareVideos.com about ESXi 4.1 Lockdown Mode and the new Total Lockdown Mode. ESXi lockdown mode is designed to put a layer of security at the local host level and require that the host be managed only through vCenter. David points out that you can go even further in locking down the local host access with the Total Lockdown Mode which completely disables the DCUI. I am not 100% sure that this is best suited for me but I guess I could see some possible applications of this mode.
Check out the video here.